Dr. Baskar Bakthavachalu, Senior Scientist, Tata Institute for Genetics and Society, Bangalore, has been awarded the prestigious SERB Science and Technology Award for Research (SERB-STAR), instituted to recognize and reward the outstanding performance of Principal Investigators of SERB projects. Baskar and his team studied the intrinsically disordered region (IDR) of the protein Ataxin-2 and its role in the formation of granules or amyloid filaments inside neurons. Their findings indicate that the IDR domain, though assists in the development of long-term memory, also causes specific forms of neurodegeneration. They deduce that this may be because the mechanisms that allow the formation and clearance of granules under normal conditions lean towards granule accumulation in diseased conditions. Baskar’s group is currently studying the cellular mechanism that regulates the Ataxin-2 granule assembly and also exploring therapeutic strategies to block/clear Ataxin-2 granules in iPSC and mouse ALS models.
Related Posts
Test! Test! Test!
By Hemalatha Rao, Varun Chopra, Sonia Sen Illustrations by Hemalatha Rao As we sit... read more
Farah Ishtiaq talks about her adventures as a field ecologist and using evolutionary ecology to understand how vector-borne diseases spread.
Dr Farah Ishtiaq is a Senior Scientist at TIGS, and she uses... read more
Sonia Sen talks about how her exposure to nature led her to study the brains of flies and mosquitoes
Sonia’s group at TIGS studies the development and the evolution of the... read more
Wastewater epidemiology – The Bengaluru Story
Wastewater epidemiology is an approach where the wastewater generated by humans is... read more
Epigenetics and Health
By Dr Rakesh Mishra, Director, TIGS Organisms inherit their genetic make-up as a... read more
Harvinder Khera wins Awsar Award for Popular Science Story
Harvinder Khera, Research Scientist at TIGS, won an Awsar Best Story Award,... read more
TIGS Communications Coordinator, Ann Vinod, talks about her journey into science communication
Ann Vinod, Communications Coordinator, Tata Institute for Genetics and Society, has around... read more
Baskar Bakthavachalu awarded The Wellcome Trust/DBT India Alliance Fellowship
Baskar Bakthavachalu, Senior Scientist at TIGS, was awarded the Wellcome Trust DBT... read more
Improving Sericulture with New Genetic Technologies
Though man discovered the use of silk cocoons in textiles some 5000... read more