Shivranjani C Moharir

Shivranjani(crpfi)

Shivranjani C Moharir
Senior Scientist
shivranjani.c@tigs.res.in

Education

  • PhD, Centre for Cellular and Molecular Biology (CCMB), 2020
  • MSc, RTM Nagpur University, 2011

Experience

  • BCIL- Industrial Training, Mahabeej, Nagpur, 2011-2012
  • Post-doctoral research, SARS-CoV-2 surveillance in wastewater and air, CCMB, 2020-2021

Expertise

  • Cell and molecular biology, neurodegenerative diseases, pathogen surveillance

Areas of interest

  • Rare genetic disorders
  • Neuromuscular disorders
  • Infection biology

Publications

  • Detection of SARS-CoV-2 in the air in Indian hospitals and houses of COVID-19 patients, Moharir SC, Thota SC, Goel A, Thakur B, Tandel D, Reddy SM, Vodapalli A, Singh Bhalla G, Kumar D, Singh Naruka D, Kumar A, Tuli A, Suravaram S, Chander Bingi T, Srinivas M, Mesipogu R, Reddy K, Khosla S, Harshan KH, Bharadwaj Tallapaka K, Mishra RK. J Aerosol Sci. 2022 Aug;164:106002. doi: 10.1016/j.jaerosci.2022.106002. Epub 2022 Apr 26. PMID: 35495416

  • Longitudinal and Long-term Wastewater Surveillance for COVID-19: Infection dynamics and Zoning of Urban Community, Tharak A, Kopperi H, Manupati H Kiran U, C. G. Gokulan, Moharir SC, Mishra RK, Mohan VS, Int J Environ Res Public Health. 2022 Feb 25;19(5):2697. doi: 10.3390/ijerph19052697

  • Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants, SC Moharir, K Sirohi, G Swarup, Progress in Molecular Biology and Translational Science 2022.

  • Optineurin deficiency induces patchy hair loss but it is not sufficient to cause amyotrophic lateral sclerosis in mice, Moharir SC, Swarup G. Biochim Biophys Acta Mol Basis Dis. 2022 Oct 1;1868(10):166470. doi: 10.1016/j.bbadis.2022.166470. Epub 2022 Jun 21.

  • Autophagy-independent cytoprotection by optineurin from toxicity of aggregates formed by mutant huntingtin and mutant ataxin-3, Moharir SC, Raghawan AK, Ramaswamy R, Swarup G, J Biochem . 2022 Feb 4;mvac011. doi: 10.1093/jb/mvac011. Online ahead of print

  • Identification of a splice variant of optineurin which is defective in autophagy and phosphorylation, Moharir SC, Bansal M, Ramachandran G, Ramaswamy R, Rawat S, Raychaudhuri S, Swarup G, BBA Molecular Cell Research, Volume 1865, Issue 11, Part A, November 2018, Pages 1526-1538, DOI: 10.1016/j.bbamcr.2018.08.009

  • Optineurin modulates ER stress-induced signaling pathways and cell death, Ramachandran G, Moharir SC, Raghunand TR, Swarup G, Biochemical and Biophysical Research Communications, Volume 534, 1 January 2021, Pages 297-302, DOI: 10.1016/j.bbrc.2020.11.091

  • Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein, Bansal M, Moharir SC, Sailasree SP, Sirohi K, Sudhakar C, Sarathi DP, Lakshmi BJ, Buono M, Kumar S, Swarup G, 2018, Journal of Biological Chemistry, 293, 132-147, DOI: 10.1074/jbc.M117.801944

  • Autophagy receptor optineurin promotes autophagosome formation by potentiating LC3-II production and phagophore maturation, Bansal M, Moharir SC, Swarup G, 2018, Communicative and Integrative Biology, 2018 May 17;11(2):1-4, DOI: 10.1080/19420889.2018.1467189

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