Hidden genomic features of an invasive malaria vector, Anopheles stephensi, revealed by a chromosome-level genome assembly

BMC Biology | February 10, 2021

The mosquito Anopheles stephensi is a vector of urban malaria in Asia that recently invaded Africa. Studying the genetic basis of vectorial capacity and engineering genetic interventions are both impeded by limitations of a vector’s genome assembly. The existing assemblies of An. stephensi are draft-quality and contain thousands of sequence gaps, potentially missing genetic elements important for its biology and evolution.

Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi

Nature Communications | November 03, 2020

Cas9/gRNA-mediated gene-drive systems have advanced development of genetic technologies for controlling vector-borne pathogen transmission. These technologies include population suppression approaches, genetic analogs of insecticidal techniques that reduce the number of insect vectors, and population modification (replacement/alteration) approaches, which interfere with competence to transmit pathogens. Here, we develop a recoded gene-drive rescue system for population modification of the malaria vector, Anopheles stephensi

A Near-Chromosome Level Genome Assembly of Anopheles stephensi

Frontiers in Genetics | November 16, 2020

Malaria remains a major healthcare risk to growing economies like India, and a chromosome-level reference genome of Anopheles stephensi is critical for successful vector management and understanding of vector evolution using comparative genomics. We report chromosome-level assemblies of an Indian strain, STE2, and a Pakistani strain SDA-500 by combining draft genomes of the two strains using a homology-based iterative approach. 

Heinrich Reichert

The Company of Biologists Ltd

Heinrich Reichert, Professor Emeritus at the University of Basel,
Switzerland, passed away on the 13th of June 2019 after a prolonged
illness. Heinrich described himself as ‘a hedonist when it came to
science’ because he said it gave him great pleasure. It was this quality
that made working with Heinrich thrilling and deeply fulfilling.[…]

Neurotransmitter identity: A question of lineage

elifesciences | May 7, 2019

The nervous system develops from a small number of neural stems cells that generate all the different types of neurons found in an organism. First, a process of spatial patterning imparts unique molecular identities to individual neural stem cells, making them distinct from one another […]

Efficient allelic drive in Drosophila

Nature Communications | April 09, 2019

Gene-drive systems developed in several organisms result in super-Mendelian inheritance of transgenic insertions. Here, we generalize this “active genetic” approach to preferentially transmit allelic variants (allelic-drive) resulting from only a single or a few nucleotide alterations.[…]